Determining druggability
نویسندگان
چکیده
منابع مشابه
A practical view of 'druggability'.
The introduction of Lipinski's 'Rule of Five' has initiated a profound shift in the thinking paradigm of medicinal chemists. Understanding the difference between biologically active small molecules and drugs became a priority in the drug discovery process, and the importance of addressing pharmacokinetic properties early during lead optimization is a clear result. These concepts of 'drug-likene...
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ژورنال
عنوان ژورنال: Nature Reviews Drug Discovery
سال: 2007
ISSN: 1474-1776,1474-1784
DOI: 10.1038/nrd2275